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CTLA4, Mouse, Clone: ANC152.2/8H5, Abnova™

Catalog No. 89113068 Shop All Abnova Corporation Products
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89-113-068 100 μg
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Catalog No. 89-113-068 Supplier Abnova Corporation Supplier No. MAB6927
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Description

Mouse monoclonal antibody raised against CTLA4.

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq

Specifications

Antigen CTLA4
Applications ELISA, Flow Cytometry
Classification Monoclonal
Clone ANC152.2/8H5
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against CTLA4.
Dilution The optimal working dilution should be determined by the end user.
Formulation In 50mM sodium phosphate buffer, 100mM potassium chloride, 150mM NaCl, pH 7.5 (0.5mg/mL gentamicin sulfate)
Gene CTLA4
Gene Alias CD152/CELIAC3/CTLA-4/GSE/IDDM12
Gene Symbols CTLA4
Host Species Mouse
Immunogen A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1493
Test Specificity MAB6927 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory cells in Vitro. It can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model.
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG1 κ
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