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Description
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | CTSL1 |
| Applications | Immunohistochemistry (Frozen), Western Blot |
| Classification | Monoclonal |
| Clone | 33/2 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against native CTSL1. |
| Dilution | Western Blot (2 ug/mL) Immunohistochemistry (Frozen sections) (4 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | Lyophilized from 1.2% sodium acetate (2mg BSA, 0.01mg sodium azide) |
| Gene | CTSL1 |
| Gene Alias | CATL/CTSL/FLJ31037/MEP |
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