CXCR2, Mouse, Clone: 6D499, Abnova™

Mouse monoclonal antibody raised against native CXCR2.

Supplier:  Abnova Corporation MAB8050

Catalog No. 89-113-314

Description

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq

Specifications

• Antigen: CXCR2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5-5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: CXCR2
• Gene Symbols: CXCR2
• Immunogen: Native purified CXCR2 from L1.2 cells.
• Regulatory Status: RUO
• Gene ID (Entrez): 3579
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry
• Clone: 6D499
• Description: Mouse monoclonal antibody raised against native CXCR2.
• Formulation: In PBS
• Gene Alias: CD182/CDw128b/CMKAR2/IL8R2/IL8RA/IL8RB
• Host Species: Mouse
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid