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CXCR2, Mouse, Clone: eBio5E8-C7-F10, Abnova™

Catalog No. 89109084 Shop All Abnova Corporation Products
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89-109-084 100 μg
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Catalog No. 89-109-084 Supplier Abnova Corporation Supplier No. MAB10878

Description

Mouse monoclonal antibody raised against CXCR2.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq

Specifications

Antigen CXCR2
Applications Flow Cytometry, Immunohistochemistry
Classification Monoclonal
Clone eBio5E8-C7-F10
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against CXCR2.
Dilution The optimal working dilution should be determined by the end user.
Formulation In aqueous buffer (0.09% sodium azide)
Gene CXCR2
Gene Alias CD182/CDw128b/CMKAR2/IL8R2/IL8RA/IL8RB
Gene Symbols CXCR2
Host Species Mouse
Immunogen Human CXCR2.
Purification Method Affinity purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3579
Test Specificity The monoclonal antibody reacts with human CXCR2, a 67-70 kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family.
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG1 κ
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