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Cyclin B1 Antibody (CCNB1/1098), Novus Biologicals™
Mouse Monoclonal Antibody
$265.00 - $506.50
Specifications
| Antigen | Cyclin B1 |
|---|---|
| Clone | CCNB1/1098 |
| Concentration | 0.2mg/mL |
| Dilution | Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml |
| Applications | Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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NBP24468700
|
Novus Biologicals
NBP2446870.02MG |
0.02 mg |
Each for $265.00
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NBP24468701
|
Novus Biologicals
NBP2446870.1MG |
0.1 mg |
Each for $506.50
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NBP24468702
|
Novus Biologicals
NBP2446870.2MG |
0.2 mg | Item Discontinued This item has been discontinued by the supplier. Please Sign In to view product availability in your area. | N/A | |||||
Description
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Cyclin B1 Monoclonal specifically detects Cyclin B1 in Human, Mouse samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.Specifications
| Cyclin B1 | |
| 0.2mg/mL | |
| Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence | |
| Unconjugated | |
| Mouse | |
| Cancer, Cell Biology, Cell Cycle and Replication, Mitotic Regulators, Tumor Suppressors | |
| 10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| CCNB, cyclin B1, G2/mitotic-specific cyclin B1, G2/mitotic-specific cyclin-B1 | |
| CCNB1 | |
| IgG1 κ | |
| Protein A or G purified | |
| It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. |
| CCNB1/1098 | |
| Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml | |
| Monoclonal | |
| Purified | |
| RUO | |
| Human, Mouse | |
| P14635 | |
| 891 | |
| Recombinant human full-length CCNB1 protein | |
| Primary | |
| Store at 4C. |
For Research Use Only
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