Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Mouse anti-Cyclin B1, Clone: SPM619, Novus Biologicals™

Mouse Monoclonal Antibody

$129.00 - $299.00

Specifications

Antigen Cyclin B1
Clone SPM619
Concentration 0.2mg/mL
Immunogen Recombinant human full-length CCNB1 protein
Gene ID (Entrez) 891
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NBP24468800 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2446880.02MG
0.02 mg Each for $129.00
Add to cart
 
NBP24468801 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2446880.1MG
0.1 mg Each for $299.00
Add to cart
 
NBP24468802 View Documents Novus BiologicalsSupplier Diversity Partner
NBP2446880.2MG
0.2 mg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Cyclin B1 Monoclonal antibody specifically detects Cyclin B1 in Human, Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications

Specifications

Cyclin B1
0.2mg/mL
891
Monoclonal
Mouse
IgG1 Kappa
Purified
RUO
Protein A or G purified
SPM619
Recombinant human full-length CCNB1 protein
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Primary
It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
Unconjugated
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Store at 4C.

For Research Use Only

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit