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MilliporeSigma™ Mouse anti-Derlin-1, Clone: 8G11.2,

Catalog No. MABS1154 Shop All MilliporeSigma Products
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MABS1154 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects Derlin-1 clone: 8G11.2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Derlin-1 (UniProt Q9BUN8; also known as Degradation in endoplasmic reticulum protein 1, Der1-like protein 1, DERtrin-1) is encoded by the DERL1 (also known as DER1) gene (ORF UNQ243/PRO276; Gene ID 79139) in human. Derlins are integral ER membrane proteins that form homo-oligomers and heteromultimeric complexes with membrane-bound machinery, including the E3 ubiquitin ligase Hrd1 and its binding partner SEL1L, involved in ER-associated degradation (ERAD). Before ERAD substrates can be processed by the cytoplasmic ubiquitin-proteasome system, they need to be translocated across the ER membrane through an AAA ATPase p97/VCP-driven process. Derlins are inactive members of the rhomboid family of intramembrane proteases that mediate the recruitment of AAA ATPase p97/VCP through interaction via their C-terminal SHP boxes. Derlin-1 is proposed to contain four transmembrane segments (a.a. 23-43, 60-80, 106-126, 155-175), three cytoplasmic domains (a.a. 23-43, 60-80, 106-126, 155-175), and two lumenol (a.a. 44-59 & 127-154) domains.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Derlin-1
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 8G11.2
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q9BUN8
Gene Symbols DERL1; DER1; UNQ243/PRO276
Host Species Mouse
Immunogen GST-tagged recombinant human derlin-1 C-terminal cytoplasmic fragment.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_001128143
Target Species Human, Mouse
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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