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  6. Mouse anti-DOG1/TMEM16A, Clone: DG1/447, Azide Free, Novus Biologicals™

Mouse anti-DOG1/TMEM16A, Clone: DG1/447, Azide Free, Novus Biologicals™
SDP

Catalog No. p-5324061 Shop All R&D Systems Products
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0.2 mg
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Catalog No. Quantity
NBP23460302 0.2 mg
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Catalog No. NBP23460302 Supplier Novus Biologicals Supplier No. NBP2346030.2 MG

Description

Mouse Monoclonal Antibody

DOG1/TMEM16A Monoclonal antibody specifically detects DOG1/TMEM16A in Human samples. It is validated for Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Specifications

Antigen DOG1/TMEM16A
Applications Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone DG1/447
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5-1.0ug/ml, ELISA 1-5ug/ml for coating, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
Formulation 10mM PBS - BSA free with No Preservative
Gene Accession No. Q5XXA6
Gene Alias ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A
Gene Symbols TMEM16A
Host Species Mouse
Immunogen Recombinant human DOG-1 protein
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55107
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Reconstitution Protein A purified
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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