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MilliporeSigma™ Mouse anti-dUTPase, Clone: 6A6.2,

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MABC608MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects dUTPase clone: 6A6.2 in Human samples, and it is validated for Immunocytochemistry, Western Blotting

Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23; also known as dUTPase, dUTP nucleotidohydrolase, or dUTP pyrophosphatase) is encoded by the DUT gene (Entrez Gene ID 1854) in human. dUTPase catalyzes the hydrolysis of dUTP to generate dUMP. This reaction serves to provide dUMP of thymine nucleotides synthesis needed for DNA replication. dUTP hydrolysis by dUTPase also prevents increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. The DUT gene encodes both mitochondrial and nuclear dATPase (DUT-M and DUT-N, respectively) via alternative splicing. DUT-N (164 aa, 17.7kDa) corresponds to DUT-M (252 aa, 26.6kDa) with the first 93 amino acid sequence replaced by MPCSE. Anti-dUTPase, clone 6A6.2, is a purified mouse monoclonal antibody. A GST fusion protein containing the full-lenght human DUT-N (UniProt P33316) sequence was used as the immunogen. The binding epitope of clone 6A6.2 is not yet mapped.
TRUSTED_SUSTAINABILITY

Specifications

Antigen dUTPase
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 6A6.2
Formulation Purified mouse monoclonal IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P33316
Gene Symbols DUT
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to human dUTPase.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001020419
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only

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