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Mouse anti-E-Cadherin, Clone: CDH1/1121 + CDH1/1122, Novus Biologicals™
SDP

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2447200.2MG

Catalog No. NBP24472002

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.


Description

Description

Ensure accurate, reproducible results in Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Specifications

Specifications

E-Cadherin
Monoclonal
0.2mg/mL
Western Blot 0.5 - 1.0 ug/ml, Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
P12830
CDH1
Recombinant fragment (119 Amino acid residues around aa 400-500) of human E-Cadherin protein
0.2 mg
Cancer, Cell Cycle and Replication, Cellular Markers, Extracellular Matrix, Plasma Membrane Markers, Signal Transduction
999
Human, Mouse
Purified
Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
CDH1/1121 + CDH1/1122
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Arc-1, cadherin 1, E-cadherin (epithelial), cadherin 1, type 1, E-cadherin (epithelial), cadherin-1, calcium-dependent adhesion protein, epithelial, CAM 120/80, CD324, CD324 antigen, CDHE, cell-CAM 120/80, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVOE-Cadherin, uvomorulin
Mouse
Protein A or G purified
RUO
Primary
Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Store at 4C.
IgG
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