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E2F1, Mouse, Clone: 2, Abnova™

Catalog No. 89113026 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-113-026 100 μg
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Catalog No. 89-113-026 Supplier Abnova Corporation Supplier No. MAB6761

Description

Mouse monoclonal antibody raised against synthetic phosphopeptide of E2F1.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq

Specifications

Antigen E2F1
Applications ELISA, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone #2
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic phosphopeptide of E2F1.
Dilution Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In antiserum (0.05% sodium azide)
Gene E2F1
Gene Alias E2F-1/RBAP1/RBBP3/RBP3
Gene Symbols E2F1
Host Species Mouse
Immunogen Synthetic phosphopeptide corresponding to residues surrounding S364 of human E2F1.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1869
Test Specificity This antibody reacts with human E2F1 phosphorylated at Ser364.
Target Species Human
Content And Storage Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2b κ
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