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MilliporeSigma™ Mouse anti-EBI3 (Neutralizing), Clone: V1.4H6.25,

Catalog No. MABF836MI Shop All MilliporeSigma Products
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MABF836MI 100 μg
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Catalog No. MABF836MI Supplier MilliporeSigma™ Supplier No. MABF836
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Description

Mouse Monoclonal Antibody

Specifically detects EBI3 (Neutralizing) clone: V1.4H6.25 in Mouse samples, and it is validated for Neutralization, Western Blotting

EBI3/IL27B is the beta subunit of the functional cytokine IL-27. The beta subunit is required for activity. IL-27 is a critical cytokine of mammalian innate immune response. IL-27 has both pro and anti-inflammatory activities. IL-27 regulates T-helper cell development and differentiation into TH1, TH2 and TH17 effector cells. IL-27 also is important in isotype switching for B-cells, and it drives rapid clonal expansion of native but not memory CD4 cells. IL-27 is also important for its anti-tumor and anti-angiogenic activity on tumor and cancer cells. The beta subunit EBI3/IL27B is also a component of IL-35 which is a heterodimer of IL-12alpha and IL-27B/EBI3. IL-35 plays a role in immune suppression. IL-27 is a secreted cytokine, thus IL-27beta subunit is expressed intracellularly associated with the endoplasmic reticulum and membrane vesicles and is detected extracellularly as part of the mature cytokine as well.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EBI3 (Neutralizing)
Applications Neutralization, Western Blot
Classification Monoclonal
Clone V1.4H6.25
Formulation Purified mouse monoclonal IgG3κ in buffer containing PBS without preservatives.
Gene Accession No. O35228
Gene Symbols Ebi3; Il27b
Host Species Mouse
Immunogen Recombinant protein corresponding to mouse EBI3/IL-35.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation and Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_056581
Target Species Mouse
Content And Storage Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Form Purified
Isotype IgG3 κ
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