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MilliporeSigma™ Mouse anti-EGR1, Clone: 16A10.1,

Catalog No. MABC1023 Shop All MilliporeSigma Products
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MABC1023 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects EGR1 clone: 16A10.1 in Human samples, and it is validated for Immunocytochemistry, Western Blotting

Early growth response protein 1 (UniProt P18146; also known as AT225, EGR-1, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24) is encoded by the EGR1 (also known as KROX24, ZNF225) gene (Gene ID 1958) in human. EGR-1 is the founding member of the early growth response (EGR) family of Cys2-His2-type zinc finger transcription factors that share a high homology in their DNA-binding region. EGR-1 is ubiquitously expressed in many cell types and binds to a consensus DNA motif (GCGGTGGGCG) in target genes, including c-Myc, cyclins D2 & G2, p19, TNF, IL-2, CD44, and ICAM-1. EGR1 is known as an immediate-early response gene due to the rapid kinetics of its induction by various signals, including growth factors, cytokines, and stress. Human EGR-1 is a 543-amino acid protein with three C2H2-type Zinc fingers (a.a. 338-362, 368-390, 396-418).
TRUSTED_SUSTAINABILITY

Specifications

Antigen EGR1
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 16A10.1
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P18146
Gene Symbols EGR1; KROX24; ZNF225
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to an internal fragment of human EGR1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001955
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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