ERBB2, Mouse, Clone: N24, Abnova™

Catalog No.	Quantity
89-110-707	100 μg

Catalog No. 89-110-707 Supplier Abnova Corporation Supplier No. MAB1913

Description

Mouse monoclonal antibody raised against native ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Specifications

• Antigen: ERBB2
• Applications: Immunofluorescence, Immunoprecipitation
• Classification: Monoclonal
• Clone: N24
• Conjugate: Unconjugated
• Description: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
• Formulation: In PBS (0.08% sodium azide)
• Gene: ERBB2
• Gene Alias: CD340, HER-2, HER-2/neu, HER2, NEU, NGL, TKR1
• Gene Symbols: ERBB2
• Host Species: Mouse
• Immunogen: Native purified ERBB2 from intact SKBR-3 breast cancer cells.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2064
• Content And Storage: Store at -20°C. Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1