MilliporeSigma™ Mouse anti-ERK3, Clone: 4E8,

Catalog No.	Quantity
MABS815MI	100 μL

Catalog No. MABS815MI Supplier MilliporeSigma™ Supplier No. MABS815

Description

Mouse Monoclonal Antibody

Specifically detects ERK3 clone: 4E8 in Human samples, and it is validated for ELISA, Flow Cytometry, Western Blotting

ERK3 (Extracellular signal-regulated kinase 3, MAPK6, p97 MAPK) belongs to the Ser/Thr protein kinase family and is a member of the mitogen-activated protein (MAP) kinase superfamily. Unlike the other members of the MAPK family, ERK3 is a mitogen-activated protein kinase homologue that has SEG motif instead of conserved TXY motif in the activation loop. Also, unlike ERK1 and ERK2, it is ubiquitously expressed and localized in the nucleus of proliferating cells. Highly unstable, ERK3 is constitutively degraded during ubiquitin-proteasome pathway of proliferating cells. ERK3 has been linked to phosphorylation MAP2 and as a possible regulator during cell differentiation.

Specifications

• Antigen: ERK3
• Applications: ELISA, Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: 4E8
• Formulation: Mouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
• Gene Accession No.: Q16659
• Gene Symbols: MAPK6; ERK3; PRKM6
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human ERK3 expressed in E. coli. 
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Ascites
• Isotype: IgG1

For Research Use Only