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ESPL1, Mouse, Clone: XJ11-4D7, Abnova™

Catalog No. 89110947 Shop All Abnova Corporation Products
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89-110-947 100 μL
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Catalog No. 89-110-947 Supplier Abnova Corporation Supplier No. MAB2347
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Description

Mouse monoclonal antibody raised against partial recombinant ESPL1.

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM

Specifications

Antigen ESPL1
Applications Immunofluorescence
Classification Monoclonal
Clone XJ11-4D7
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant ESPL1.
Dilution Immunofluorescence (1:1000) The optimal working dilution should be determined by the end user.
Formulation In buffer containing 0.09% sodium azide
Gene ESPL1
Gene Alias ESP1/FLJ46492/KIAA0165/SEPARASE/SEPARIN
Gene Symbols ESPL1
Host Species Mouse
Immunogen Recombinant fusion protein corresponding to amino acids 1866-1996 of human ESPL1.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9700
Test Specificity This antibody is specific to human separase.
Target Species Human
Content And Storage Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2a
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