F8, Mouse, Clone: 101, Abnova™

Catalog No.	Quantity
89-111-720	200 μg

Catalog No. 89-111-720 Supplier Abnova Corporation Supplier No. MAB4180

Description

Mouse monoclonal antibody raised against F8.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]

Specifications

• Antigen: F8
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 101
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against F8.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4
• Gene: F8
• Gene Alias: AHF/DXS1253E/F8B/F8C/FVIII/HEMA
• Gene Symbols: F8
• Host Species: Mouse
• Immunogen: Purified human F8.
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2157
• Test Specificity: Recognizes full-length human Factor VIII. Does not cross-react with von Willebrand factor.
• Target Species: Human
• Content And Storage: Store at -20°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1