F8, Mouse, Clone: 12, Abnova™

Catalog No.	Quantity
89-111-687	500 μg

Catalog No. 89-111-687 Supplier Abnova Corporation Supplier No. MAB4086

Description

Mouse monoclonal antibody raised against partial F8.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]

Specifications

• Antigen: F8
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 12
• Conjugate: Unconjugated
• Description: coagulation factor VIII, procoagulant component
• Formulation: Lyophilized from 10mM sodium phosphate buffer, 150mM NaCl, pH 7.4 (0.01% sodium azide)
• Gene: F8
• Gene Alias: AHF, DXS1253E, F8B, F8C, FVIII, HEMA
• Gene Symbols: F8
• Host Species: Mouse
• Immunogen: Human F8 A2 domain.
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2157
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1