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FADD, Mouse, Clone: J1D2, Abnova™

Catalog No. 89110786 Shop All Abnova Corporation Products
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89-110-786 100 μL
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Catalog No. 89-110-786 Supplier Abnova Corporation Supplier No. MAB2044
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Description

Mouse monoclonal antibody raised against partial recombinant FADD.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq

Specifications

Antigen FADD
Applications ELISA, Western Blot
Classification Monoclonal
Clone J1D2
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant FADD.
Dilution The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (0.09% sodium azide)
Gene FADD
Gene Alias GIG3/MGC8528/MORT1
Gene Symbols FADD
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 1-208 of human FADD.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8772
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2b κ
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