FADD, Mouse, Clone: J1D2, Abnova™

Mouse monoclonal antibody raised against partial recombinant FADD.

Supplier:  Abnova Corporation MAB2044

Catalog No. 89-110-786

Description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq

Specifications

• Antigen: FADD
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: FADD
• Gene Symbols: FADD
• Immunogen: Recombinant protein corresponding to amino acids 1-208 of human FADD.
• Regulatory Status: RUO
• Gene ID (Entrez): 8772
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2b κ

• Applications: ELISA, Western Blot
• Clone: J1D2
• Description: Mouse monoclonal antibody raised against partial recombinant FADD.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: GIG3/MGC8528/MORT1
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid