Mouse anti-Fas/TNFRSF6/CD95, Clone: B-R18, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2445810.1MG
Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Frozen), ImmunofluorescenceFas/TNFRSF6/CD95 Monoclonal antibody specifically detects Fas/TNFRSF6/CD95 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Frozen, SDS-Page, Immunofluorescence.
|10mM PBS and 0.05% BSA with 0.05% Sodium Azide|
|Recombinant human CD95 protein|
|Protein A or G purified|
|Store at 4C.|
|MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.|
|Flow Cytometry, Immunohistochemistry (Frozen), SDS-Page, Immunofluorescence|
|Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml|
|Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1FASTM, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6|
|Apoptosis, Cancer, Cell Biology, Death Receptor Signaling Pathway, Diabetes Research, Inhibitors Activators and Regulators|
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