MilliporeSigma™ Mouse anti-FCGR2A/C, Clone: 11B6,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABF841

Catalog No. MABF841

Description

Specifically detects FCGR2A/C clone: 11B6 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blotting

FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2 represent the four known classes of IgG Fc receptors (FcγRs). FcγRII, FcγRIII, and FcγRIV are low-affinity receptors for monomeric IgG, whereas FcγRI is the only high-affinity FcγR. FcγRs play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. In addition to binding immune complex (IC), FcγRs have been shown to bind non-IgG ligands. For example, FcγRII is shown to bind oxLDL, while FcγRIII binding to an E. coli component is reported to negatively regulate the function of macrophage receptor with collagenous structure (MARCO). FcyRII activation is also reported to transduce a negative regulatory signal against CD38 cross-linking-induced proliferation of resting mature B cells. Low affinity immunoglobulin gamma Fc region receptor II-a/b/c (IgG Fc receptor II-a/-b/-c, CDw32, Fc-gamma RII-a/-b/-c, Fc-gamma-RIIa/b/c, FcRII-a/-b/-c, CD32) are encoded by the FCGR2A/B/C (CD32, FCG2, IGFR2) genes in human (UniProt P12318, P31994, P31995; Gene ID 2212, 2213, 9103). The FcγRIIs encoded by the three genes are highly conserved in their extracellular portion, with significant variation in the transmembrane and intracellular regions. All three types of transcripts alternative splicing to generate additional isoforms.

Specifications

• Antigen: FCGR2A/C
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: CD32; FCG2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; IGFR2
• Immunogen: Linear peptide corresponding to a cytoplasmic domain sequence identical in human FcγRIIa and FcγRIIc.
• Quantity: 100 μg
• Research Discipline: Inflammation and Immunology
• Gene ID (Entrez): NP_001129691.1; NP_963857.3
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 11B6
• Gene Accession No.: P12318; P31995
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only