FCGR3A, Mouse, Clone: GRM1, Abnova™

Mouse monoclonal antibody raised against native FCGR3A.

Supplier:  Abnova Corporation MAB4970

Catalog No. 89-112-021

Description

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: FCGR3A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (20 uL/10⁶ cells) The optimal working dilution should be determined by the end user.
• Gene: FCGR3A
• Gene Symbols: FCGR3A
• Immunogen: Normal human peripheral blood granulocytes.
• Regulatory Status: RUO
• Gene ID (Entrez): 2214
• Content And Storage: Store in the dark at 4°C. Avoid prolonged exposure to light.
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunofluorescence
• Clone: GRM1
• Description: Mouse monoclonal antibody raised against native FCGR3A.
• Formulation: In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide)
• Gene Alias: CD16/CD16A/FCG3/FCGR3/FCGRIII/FCR-10/FCRIII/FCRIIIA/IGFR3
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid