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FCGR3A, Mouse, Clone: LNK16, Abnova™

Catalog No. 89108287 Shop All Abnova Corporation Products
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100 μg
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89-108-287 100 μg
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Catalog No. 89-108-287 Supplier Abnova Corporation Supplier No. MAB0959
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Description

Mouse monoclonal antibody raised against native FCGR3A.

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen FCGR3A
Applications Flow Cytometry, Immunoprecipitation
Classification Monoclonal
Clone LNK16
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against native FCGR3A.
Dilution The optimal working dilution should be determined by the end user.
Formulation In TBS, pH 8.0 (0.09% sodium azide)
Gene FCGR3A
Gene Alias CD16/CD16A/FCG3/FCGR3/FCGRIII/FCR-10/FCRIII/FCRIIIA/IGFR3
Gene Symbols FCGR3A
Host Species Mouse
Immunogen Native purified FCGR3A from normal human peripheral blood granulocytes.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2214
Test Specificity This antibody reacts with CD16, a low affinity receptor for aggregated IgG (Fc gamma RIII antigen). CD16 exists in two different isoforms: CD16a (Fc gamma RIIIA; 50-65 KDa; expressed on NK-cells, monocytes and macrophages) and CD16b (Fc gamma RIIIB; 48 KDa; mainly expressed on neutrophils).
Target Species Human, Primate
Content And Storage Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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