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FCGR3A, Mouse, PE-Dyomics 647, Clone: LNK16, Abnova™

Catalog No. 89111781 Shop All Abnova Corporation Products
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89-111-781 100 Reactions
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Catalog No. 89-111-781 Supplier Abnova Corporation Supplier No. MAB4362

Description

Mouse monoclonal antibody raised against native FCGR3A.

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen FCGR3A
Applications Flow Cytometry, Immunoprecipitation
Classification Monoclonal
Clone LNK16
Conjugate PE-Dyomics 647
Description Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Formulation In PBS (0.2% BSA, 0.09% sodium azide)
Gene FCGR3A
Gene Alias CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Gene Symbols FCGR3A
Host Species Mouse
Immunogen Native purified FCGR3A from normal human peripheral blood granulocytes.
Quantity 100 Reactions
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2214
Test Specificity This antibody reacts with CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA; 50-65kDa; expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB; 48kDa; mainly expressed on neutrophils).
Target Species Human, Non-human Primate
Content And Storage Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.
Isotype IgG1
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