FKBP4, Mouse, Clone: AT4D3, Abnova™

Mouse monoclonal antibody raised against full-length recombinant FKBP4.

Supplier:  Abnova Corporation MAB3587

Catalog No. 89-111-489

Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several nontranscribed pseudogenes similar to this gene. [provided by RefSeq

Specifications

• Antigen: FKBP4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: FKBP4
• Gene Symbols: FKBP4
• Immunogen: Recombinant protein corresponding to full length human FKBP4.
• Regulatory Status: RUO
• Gene ID (Entrez): 2288
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2b κ

• Applications: ELISA, Western Blot
• Clone: AT4D3
• Description: Mouse monoclonal antibody raised against full length recombinant FKBP4.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: FKBP52/FKBP59/HBI/Hsp56/PPIase/p52
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid