FLT3, Mouse, Clone: BV10A4, Abnova™

Catalog No.	Quantity
89-113-379	100 μg

Catalog No. 89-113-379 Supplier Abnova Corporation Supplier No. MAB8212

Description

Mouse monoclonal antibody raised against native FLT3.

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq

Specifications

• Antigen: FLT3
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: BV10A4
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native FLT3.
• Dilution: Flow Cytometry (10 ug/mL per 10⁶ cells/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene: FLT3
• Gene Alias: CD135/FLK2/STK1
• Gene Symbols: FLT3
• Host Species: Mouse
• Immunogen: Native purified FLT3 from BV-173 leukemic cell line.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2322
• Test Specificity: This antibody reacts with FLT3, a 130-160 KDa type III receptor tyrosine kinase that is involved in early steps ofhematopoiesis.
• Target Species: Human
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1