FOLH1, Mouse, Clone: GCP-05, Abnova™

Catalog No.	Quantity
89-111-499	100 μg

Catalog No. 89-111-499 Supplier Abnova Corporation Supplier No. MAB3611

Description

Mouse monoclonal antibody raised against partial recombinant FOLH1.

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq

Specifications

• Antigen: FOLH1
• Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation
• Classification: Monoclonal
• Clone: GCP-05
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant FOLH1.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene: FOLH1
• Gene Alias: FGCP/FOLH/GCP2/GCPII/NAALAD1/NAALAdase/PSM/PSMA/mGCP
• Gene Symbols: FOLH1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 44-750 of human FOLH1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2346
• Test Specificity: This antibody recognizes extracellular domain of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 KDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
• Target Species: Human
• Content And Storage: Store at 4°C. Do not freeze.
• Form: Liquid
• Isotype: IgG1