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GATA3 Mouse, Brilliant Violet 711, Clone: L50-823, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565449

Catalog No. BDB565449



Description

Description

GATA3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This ~50-kDa nuclear protein regulates the development and subsequent maintenance of multiple tissues. GATA3 is involved in the development of T lymphocytes (regulates T cell receptor subunit gene expression) and the differentiation of mature T cells to become Th2 cells. The expressed levels of normal or mutant GATA3 are also associated with the behaviors of various cancer cells including estrogen receptor-positive breast carcinoma cells.

The L50-823 monoclonal antibody recognizes human and mouse GATA3.

The antibody was conjugated to BD Horizon BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

Specifications

Specifications

GATA3
L50-823
Gata-3; GATA binding protein 3; GATA-binding factor 3; HDR
Affinity Purified
Conserved peptide between the trans-activation and DNA-binding domains of human
Affinity Chromatography
RUO
Primary
Human, Murine
Flow Cytometry, Immunocytochemistry
Brilliant Violet 711
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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