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Description
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq
Specifications
Specifications
| Antigen | GCG |
| Applications | Immunohistochemistry (PFA fixed) |
| Classification | Monoclonal |
| Clone | K79bB10 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against native GCG. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | Lyophilized from 1.2% sodium acetate (2mg BSA, 0.01mg sodium azide) |
| Gene | GCG |
| Gene Alias | GLP1/GLP2/GRPP |
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