GCK, Mouse, Clone: 4G6, Abnova™

Catalog No.	Quantity
89-108-865	100 μL

Catalog No. 89-108-865 Supplier Abnova Corporation Supplier No. MAB10666

Description

Mouse monoclonal antibody raised against partial recombinant GCK.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with noninsulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq

Specifications

• Antigen: GCK
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 4G6
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant GCK.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: GCK
• Gene Alias: GK/GLK/HHF3/HK4/HKIV/HXKP/MODY2
• Gene Symbols: GCK
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human GCK.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2645
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1