GP1BA, Mouse, Clone: SZ2, Abnova™

Catalog No.	Quantity
89-111-714	200 μg

Catalog No. 89-111-714 Supplier Abnova Corporation Supplier No. MAB4144

Description

Mouse monoclonal antibody raised against native GP1BA.

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq

Specifications

• Antigen: GP1BA
• Applications: Flow Cytometry, Immunoprecipitation
• Classification: Monoclonal
• Clone: SZ2
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native GP1BA.
• Dilution: Flow Cytometry (2ug/5x10⁶ platelets/test) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from PBS (1mg/mL BSA)
• Gene: GP1BA
• Gene Alias: BSS/CD42B/CD42b-alpha/GP1B/MGC34595
• Gene Symbols: GP1BA
• Host Species: Mouse
• Immunogen: Native purified GP1BA from human washed platelets.
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2811
• Test Specificity: The molecular weight of the recognized antigen is 160KDa. Reacts with glycoprotein Ib on megakaryocytes and platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetin induced platelet agglutination. Inhibits platelet aggregation induced by Type I collagen and platelet activating factor (PAF). Immunoprecipitates the components of glycoprotein Ib complex.
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1