GSTM1, Mouse, Clone: 10H6, Abnova™

Catalog No.	Quantity
89-113-721	3 x 1 mL

Catalog No. 89-113-721 Supplier Abnova Corporation Supplier No. MAB9662

Description

Mouse monoclonal antibody raised against partial recombinant GSTM1.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]

Specifications

• Antigen: GSTM1
• Applications: Immunohistochemistry
• Classification: Monoclonal
• Clone: 10H6
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant GSTM1.
• Dilution: Immunohistochemistry (1:40-1:80) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from tissue culture supernatant (0.09% sodium azide)
• Gene: GSTM1
• Gene Alias: GST1/GSTM1-1/GSTM1a-1a/GSTM1b-1b/GTH4/GTM1/H-B/MGC26563/MU/MU-1
• Gene Symbols: GSTM1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to GSTM1.
• Quantity: 3 x 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2944
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with sterile distilled water store at 4°C for at least two months. For long term storage store at -20°C or below. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgM