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Description
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq
Specifications
Specifications
| Antigen | HFE |
| Applications | ELISA, Immunofluorescence, Western Blot |
| Classification | Monoclonal |
| Clone | 3F1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant HFE. |
| Dilution | ELISA (1:10000) Western Blot (1:500-1:2000) Immunofluorescence (1:200-1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | In ascites (0.03% sodium azide) |
| Gene | HFE |
| Gene Alias | HFE1/HH/HLA-H/MGC103790/dJ221C16.10.1 |
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