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MilliporeSigma™ Mouse anti-HGPRT, Clone: 13H11.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS528

Catalog No. MABS528MI


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Description

Description

Specifically detects HGPRT clone: 13H11.1 in Human samples, and it is validated for Western Blotting

Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8; UniProt P00492; also known as HGPRT, HGPRTase) is encoded by the HPRT1 (also known as HGPRT, HPRT) gene (Gene ID 3251) in human. HPRT is a purine salvage enzyme that catalyzes the condensation of 5-phosphoribosyl 1-pyrophosphate (PRPP) and hypoxanthine or guanine to form inosine 5-monophosphate (IMP) and guanosine 5-monophosphate (GMP), respectively. PRPP is an essential compound for the de novo pathway of purine synthesis as well as the synthesis of pyrimidine compounds. PRPP concentrations in erythrocyte are markedly increased in individuals with HPRT deficiency. Complete HPRT deficiency leads to Lesch–Nyhan disease (LND) characterized by uric acid overproduction, motor dysfunction, cognitive disability, and self-injurious behavior. Partial deficiency of HPRT activity causes Lesch–Nyhan variant (LNV) characterized by hyperuricemia and variable degree of neurological manifestations, depending on the residual enzyme activity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HGPRT
Monoclonal
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
HPRT1; HPRT
GST-tagged human HGPRT recombinant fragment lacking N- and C-terminal regions.
100 μg
Signaling
NP_000185
Stable for one year at 2°C to 8°C from date of receipt.
IgG2b κ
Western Blot
13H11.1
P00492
Mouse
Protein G Purified
RUO
Primary
Human
Purified
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