HLA-A2, Mouse, Clone: BB7.2, Abnova™

Mouse monoclonal antibody raised against HLA-A2.

Supplier:  Abnova Corporation MAB6434

Catalog No. 89-112-866

Description

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq

Specifications

• Antigen: HLA-A2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Description: Mouse monoclonal antibody raised against HLA-A2.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: HLAA
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes an epitope at the C-terminus of alpha-2 helix and a turn onone of the underlying beta strands within the human HLA-A2 histocompatibility antigen.
• Content And Storage: Store at 4°C. Do not freeze.
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: BB7.2
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: HLA-A
• Gene Symbols: HLA-A
• Immunogen: HLA-A2 solubilised by papain.
• Regulatory Status: RUO
• Gene ID (Entrez): 3105
• Target Species: Human
• Form: Liquid