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HLA-A2, Mouse, Clone: BB7.2, Abnova™

Catalog No. 89112866 Shop All Abnova Corporation Products
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89-112-866 100 μg
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Catalog No. 89-112-866 Supplier Abnova Corporation Supplier No. MAB6434
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Description

Mouse monoclonal antibody raised against HLA-A2.

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq

Specifications

Antigen HLA-A2
Applications Flow Cytometry, Immunoprecipitation
Classification Monoclonal
Clone BB7.2
Concentration 1 mg/mL
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against HLA-A2.
Dilution The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (0.09% sodium azide)
Gene HLA-A
Gene Alias HLAA
Gene Symbols HLA-A
Host Species Mouse
Immunogen HLA-A2 solubilised by papain.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3105
Test Specificity This antibody recognizes an epitope at the C-terminus of alpha-2 helix and a turn onone of the underlying beta strands within the human HLA-A2 histocompatibility antigen.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Form Liquid
Isotype IgG2b
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