HLA-E, Mouse, Clone: MEM-E/08, Abnova™

Mouse monoclonal antibody raised against recombinant HLA-E.

Supplier:  Abnova Corporation MAB3632

Catalog No. 89-111-508

Description

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq

Specifications

• Antigen: HLA-E
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: HLA-E
• Gene Symbols: HLA-E
• Immunogen: Recombinant protein corresponding to human HLA-E.
• Regulatory Status: RUO
• Gene ID (Entrez): 3133
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: MEM-E/08
• Description: Mouse monoclonal antibody raised against recombinant HLA-E.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: DKFZp686P19218/EA1.2/EA2.1/HLA-6.2/MHC/QA1
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that antibody is remarkably specific to HLA-E, only with weak cross-reactivity with following classical MHC Class I molecules (MHC Class Ia) : HLA-A24, -B7, -B27, -B51, -B54, -C7.
• Content And Storage: Store at 4°C. Do not freeze.
• Isotype: IgG1