MilliporeSigma™ Mouse anti-Homeobox protein CDX-2, Clone: 7D9.1,

Catalog No.	Quantity
MABE988MI	100 μg

Catalog No. MABE988MI Supplier MilliporeSigma™ Supplier No. MABE988

Description

Mouse Monoclonal Antibody

Specifically detects Homeobox protein CDX-2 clone: 7D9.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Homeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.

Specifications

• Antigen: Homeobox protein CDX-2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 7D9.1
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q99626
• Gene Symbols: CDX2; CDX3
• Host Species: Mouse
• Immunogen: GST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001256
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only