MilliporeSigma™ Mouse anti-Homeobox protein CDX-2, Clone: 7D9.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE988

Catalog No. MABE988MI

Description

Specifically detects Homeobox protein CDX-2 clone: 7D9.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Homeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.

Specifications

• Antigen: Homeobox protein CDX-2
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: CDX2; CDX3
• Immunogen: GST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_001256
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 7D9.1
• Gene Accession No.: Q99626
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only