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CD11b Mouse anti-Human, Brilliant Violet 786, Clone: ICRF44 (also known as 44), BD Optibuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 740965

Catalog No. BDB740965


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Description

Description

The ICRF44 monoclonal antibody specifically binds to CD11b, the 165-kDa adhesion glycoprotein that associates with the 95-kDa integrin β 2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is a type I transmembrane glycoprotein that is encoded by ITGAM (Integrin alpha M). It is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP.

Specifications

Specifications

CD11b
ICRF44 (also known as 44)
Brilliant Violet 786
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
MAC-1A; Mac-1; ITGAM; Integrin alpha M; CR3A; CR-3 alpha; Mo1; SLEB6
Affinity Purified
Human monocytes
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Documents
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