CD2 Mouse anti-Human, Brilliant Violet 711, Clone: RPA-2.10, BD Optibuild™
Mouse Monoclonal Antibody
Supplier: BD Biosciences 740767
The RPA-2.10 monoclonal antibody specifically binds to CD2. CD2 is a 50 kDa single-chain transmembrane glycoprotein, also known as LFA-2 or the receptor for sheep erythrocytes. CD2 belongs to the immunoglobulin superfamily of proteins along with its ligand LFA-3, CD58. It is present on about 80-90% of human peripheral blood lymphocytes, greater than 95% of thymocytes, all T lymphocytes that form E-rosettes and a subset of NK cells. CD2 plays a role in T-cell signaling and in lymphocyte adhesion.
The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
|LFA-2; Lymphocyte function antigen-2; T11/Leu-5; Rosette receptor|
|Brilliant Violet 711|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Human Phytohemagglutinin-treated Lymphoblasts|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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