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CD23 Mouse anti-Human, Brilliant Violet 510, Clone: M-L233, BD Optibuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 740178

Catalog No. BDB740178


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Description

Description

The M-L233 antibody specifically binds to human CD23, the low affinity receptor for human IgE (Fc ε RII). CD23 is a type II membrane glycoprotein that can be expressed by B cells, monocytes, macrophages, eosinophils, platelets and dendritic cells. CD23 can mediate IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. Soluble CD23 (sCD23) can be released by CD23-positive cells as a result of proteolytic cleavage of membrane CD23. Larger fragments of sCD23 (e.g., 25-37 kDa) retain their IgE-binding capacity whereas smaller fragments (i.e., ≤ 12 kDa) do not. Soluble CD23 may have immunoregulatory effects on the growth and differentiation of B cells and other cell types.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.

Specifications

Specifications

CD23
M-L233
Brilliant Violet 510
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Flow Cytometry
0.2mg/mL
FCER2; FcεRII; Low affinity immunoglobulin epsilon Fc receptor; BLAST-2
Affinity Purified
IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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