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CD23 Mouse anti-Human, Brilliant Violet 711, Clone: M-L233, BD Optibuild™

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BDB740790 50 μg
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Catalog No. BDB740790 Supplier BD Biosciences Supplier No. 740790
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Description

Mouse Monoclonal Antibody

The M-L233 antibody specifically binds to human CD23, the low affinity receptor for human IgE (Fc ε RII). CD23 is a type II membrane glycoprotein that can be expressed by B cells, monocytes, macrophages, eosinophils, platelets and dendritic cells. CD23 can mediate IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. Soluble CD23 (sCD23) can be released by CD23-positive cells as a result of proteolytic cleavage of membrane CD23. Larger fragments of sCD23 (e.g., 25-37 kDa) retain their IgE-binding capacity whereas smaller fragments (i.e., ≤ 12 kDa) do not. Soluble CD23 may have immunoregulatory effects on the growth and differentiation of B cells and other cell types.

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD23
Applications Flow Cytometry
Classification Monoclonal
Clone M-L233
Concentration 0.2mg/mL
Conjugate Brilliant Violet 711
Description FCER2; FcεRII; Low affinity immunoglobulin epsilon Fc receptor; BLAST-2
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only

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