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CD274 Mouse anti-Human, Brilliant Violet 510, Clone: MIH1, BD Optibuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 740190

Catalog No. BDB740190

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PD-L1 and PD-L2 are newly discovered members of the B7 family are the ligands for the program death 1 (PD-1) receptor. They are expressed on immature dendritic cells and mature dendritic cells. PD-L1, also called B7-H1, is expressed on antigen-presenting cells, including IFN- γ-stimulated monocytes, and activated human and murine dendritic cells. Monoclonal antibodies that block PD-L1 and PD-L2 on dendritic cells result in enhanced T cell proliferation and cytokine production. PD-L1 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. Studies show overlapping functions of PD-L1 and PD-L2 and indicate an important role for the PD-L:PD-1 pathway in regulating T cell responses.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.



Brilliant Violet 510
Aqueous buffered solution containing ≤0.09% sodium azide.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Flow Cytometry
B7-H1, PD-L1
Affinity Purified
IgG1, κ
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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