CD33 Mouse anti-Human, Brilliant Violet 786, Clone: WM53 (also known as WM-53), BD Optibuild
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 740974
The WM53 monoclonal antibody specifically binds to human CD33. CD33 is a 67 kDa type I transmembrane glycoprotein. It is expressed on monocytes, activated T cells, myeloid progenitors, mast cells and weakly on polymorphonuclear cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. Reports indicate that this glycoprotein can function as a sialic acid-dependent cell adhesion molecule and this function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
The antibody was conjugated to BD Horizon BV786 which is part of the BD Horizon Brilliant Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy7-like dyes (eg, 780/60-nm filter).
|WM53 (also known as WM-53)|
|Brilliant Violet 786|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Siglec-3; SIGLEC3; Sialic acid-binding Ig-like lectin 3; p67; gp67; My9|
|Acute Myeloid Leukemia Blasts|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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