CD33 Mouse anti-Human, Brilliant Violet 786, Clone: WM53 (also known as WM-53), BD Optibuild™
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 740974
The WM53 monoclonal antibody specifically binds to human CD33. CD33 is a 67 kDa type I transmembrane glycoprotein. It is expressed on monocytes, activated T cells, myeloid progenitors, mast cells and weakly on polymorphonuclear cells. CD33 is absent on normal platelets, lymphocytes, erythrocytes, and hematopoietic stem cells. Reports indicate that this glycoprotein can function as a sialic acid-dependent cell adhesion molecule and this function can be modulated by endogenous sialoglycoconjugates when CD33 is expressed on the membrane.
The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).
|WM53 (also known as WM-53)|
|Brilliant Violet 786|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Siglec-3; SIGLEC3; Sialic acid-binding Ig-like lectin 3; p67; gp67; My9|
|Acute Myeloid Leukemia Blasts|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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