CD41a Mouse anti-Human, Brilliant Violet 605, Clone: HIP8, BD Optibuild™
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 740402
The HIP8 monoclonal antibody specifically binds to the α -chain of CD41. CD41 is also known as Integrin α IIb or Platelet GPIIb. The calcium-dependent complex of CD41 and CD61 ( β 3 integrin or GPIIIa) is normally expressed on platelets and megakaryocytes. The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. CD41 (clone HIP8) completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes.
|Brilliant Violet 605|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|ITGA2B; Integrin alpha-2b (αIIb); Platelet glycoprotein IIb (GPIIb)|
|Purified platelet membrane glycoproteins|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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