HLA-ABC Mouse anti-Human, Brilliant Violet 510, Clone: G46-2.6, BD Optibuild™

Catalog No.	Quantity
BDB740172	50 μg

Catalog No. BDB740172 Supplier BD Biosciences Supplier No. 740172

Description

Mouse Monoclonal Antibody

The Human Leukocyte Antigen (HLA) complex is the human version of the MHC, helping the immune system distinguish the body's own proteins versus those from foreign invaders, such as viruses. Humans have three main MHC class I genes, known as HLA-A, HLA-B and HLA-C. Major histocompatibility complex (MHC) class I molecules, which are widely found on the surface of nucleated cells, function by binding peptides and displaying them on the cell surface to cytotoxic T-cells. Intracellular degradation of cytosolic proteins by the proteasome generates many of the peptides that load MHC class I molecules. MHC class I may also serve as an inhibitory ligand for natural killer (NK) cell receptors (KIR, Killer Immunoglobulin-like Receptors), which viruses may modulate expression levels for to evade immune detection. The G46-2.6 monoclonal antibody binds to a monomorphic epitope on the alpha chain of HLA-A, HLA-B and HLA-C.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.

Specifications

• Antigen: HLA-ABC
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: G46-2.6
• Concentration: 0.2mg/mL
• Conjugate: Brilliant Violet 510
• Description: Major histocompatibility complex, class I, A,B,C; HLA class I A,B,C
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only