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MilliporeSigma™ Mouse anti-IDH1/2 Mutant (R132/172), Clone: MsMAb-1,

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MABC1103MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects IDH1/2 Mutant (R132/172) clone: MsMAb-1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate and carbon dioxide. There exist three forms of IDHs in human (IDH1-3), with IDH3 utilizing NAD+ as a cofactor and functioning within the citric acid cycle, while IDH1 (EC 1.1.1.42; UniProt P48735) and IDH2 (EC 1.1.1.42; UniProt P48735) utilizing NADP+ as a cofactor and functioning outside the context of the citric acid cycle. Mutated IDH1 and IDH2 convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate (2-HG) in cytosol and mitochondria, respectively. Isocitrate dehydrogenase 1 ⁄ 2 mutations have been reported in gliomas, acute myeloid leukemias (AMLs), cartilaginous tumors, osteosarcoma, Giant cell tumors of bone (GCTB), Ollier disease, and Maffucci syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDH1/2 Mutant (R132/172)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone MsMAb-1
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. O75874 (IDH1); P48735 (IDH2)
Gene Symbols IDH1; PICD; IDH2
Host Species Mouse
Immunogen KLH-conjugated peptide derived from human IDH1 sequence with R132G mutation.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) IDH1: NP_001269315; IDH2: NP_001276839
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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