IKBKB, Mouse, Clone: 10A2, Abnova™

Catalog No.	Quantity
89-108-896	100 μL

Catalog No. 89-108-896 Supplier Abnova Corporation Supplier No. MAB10695

Description

Mouse monoclonal antibody raised against partial recombinant IKBKB.

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Specifications

• Antigen: IKBKB
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 10A2
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant IKBKB.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: IKBKB
• Gene Alias: FLJ40509/IKK-beta/IKK2/IKKB/MGC131801/NFKBIKB
• Gene Symbols: IKBKB
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human IKBKB.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3551
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1