MilliporeSigma™ Mouse anti-IKBKB, Clone: 10A2,

Catalog No.	Quantity
MABS807MI	100 μL

Catalog No. MABS807MI Supplier MilliporeSigma™ Supplier No. MABS807

Description

Mouse Monoclonal Antibody

Specifically detects IKBKB clone: 10A2 in Human samples, and it is validated for Western Blotting

Inhibitor of kappa light polypeptide gene enhancer in B-cells (IKBKB), also known as kinase beta or IKK2/IKKB, is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Specifications

• Antigen: IKBKB
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 10A2
• Formulation: Mouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
• Gene Accession No.: O14920
• Gene Symbols: IKBKB; IKKB
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of IKBKB expressed in E. coli.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Ascites
• Isotype: IgG1

For Research Use Only