IL1B, Mouse, Clone: 2H12, Abnova™

Mouse monoclonal antibody raised against partial recombinant IL1B.

Supplier:  Abnova Corporation MAB9933

Catalog No. 89-113-891

Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq

Specifications

• Antigen: IL1B
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western blot (1:1000) Immunohistochemistry (1:10) The optimal working dilution should be determined by the end user.
• Gene: IL1B
• Gene Alias: IL-1/IL1-BETA/IL1F2
• Host Species: Mouse
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 3553
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: 2H12
• Description: Mouse monoclonal antibody raised against partial recombinant IL1B.
• Formulation: In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
• Gene Accession No.: NM_000576.2
• Gene Symbols: IL1B
• Immunogen: Recombinant protein corresponding to amino acids 118-269 of human IL1B.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid