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Description
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. [provided by RefSeq
Specifications
Specifications
| Antigen | INHA |
| Applications | ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed) |
| Classification | Monoclonal |
| Clone | 4A2 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant INHA. |
| Dilution | ELISA (1:10000) Immunohistochemistry (1:200-1:1000) Immunofluorescence (1:200-1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.03% sodium azide) |
| Gene | INHA |
| Gene Symbols | INHA |
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